Alternative titles; symbols
HGNC Approved Gene Symbol: PPBPP1
Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38) : 4:73,848,736-73,849,253 (from NCBI)
Beta-thromboglobulin (TGB), also known as pro-platelet basic protein (PPBP; 121010), is encoded by a member of the family of small inducible genes (SIGs), so called because of their small size and characteristic inducibility during platelet activation. PPBP and the PPBP 'like' gene (PPBPL1) are CXC SIG proteins, which contain 4 cysteine residues separated by a single amino acid residue.
Majumdar et al. (1991) demonstrated that the TGB1 gene, but not the TGB2 gene, is expressed in a megakaryocyte-specific fashion.
By pulsed field gel electrophoresis, Tunnacliffe et al. (1992) found that the TGB genes are closely linked to the PF4 genes (173460; 173461) and to several other CXC SIGs in a 700-kb Sfi1 fragment localized to chromosome 4q12-q13.
Majumdar, S., Gonder, D., Koutsis, B., Poncz, M. Characterization of the human beta-thromboglobulin gene: comparison with the gene for platelet factor 4. J. Biol. Chem. 266: 5785 only, 1991. [PubMed: 1826003]
Tunnacliffe, A., Majumdar, S., Yan, B., Poncz, M. Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4. Blood 79: 2896-2900, 1992. [PubMed: 1316786]