HGNC Approved Gene Symbol: ZNF264
Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38) : 19:57,191,500-57,222,846 (from NCBI)
Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (603971) for general information on ZNFs.
By screening human brain cDNAs for the potential to encode proteins that are at least 50 kD, Ishikawa et al. (1997) isolated a ZNF264 cDNA, which they called KIAA0412. The deduced 627-amino acid full-length ZNF264 protein shares 54.3% amino acid sequence identity with the Kruppel-related zinc finger protein ZNF184 (602277) across 385 residues. By SDS-PAGE, in vitro transcribed/translated ZNF264 had an apparent molecular mass of approximately 84 kD. RT-PCR detected ZNF264 expression in all human tissues tested, with relatively high expression in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.
By analysis of a radiation hybrid mapping panel, Ishikawa et al. (1997) mapped the ZNF264 gene to chromosome 19.
Ishikawa, K., Nagase, T., Nakajima, D., Seki, N., Ohira, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 4: 307-313, 1997. [PubMed: 9455477] [Full Text: https://doi.org/10.1093/dnares/4.5.307]