Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF266
Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38) : 19:9,412,429-9,435,573 (from NCBI)
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (604749) for additional information on zinc finger proteins.
By screening a human monoblast cell line (U-937) cDNA library with a degenerate oligonucleotide based on a conserved region of Kruppel-related zinc finger proteins that encompasses the H/C link, Abrink et al. (1995) isolated cDNAs encoding 42 distinct Kruppel-related zinc finger proteins, including ZNF266, which they called HZF1. The partial ZNF266 cDNA, which lacks 5-prime coding sequence, encodes 7 C-terminal zinc finger domains. Northern blot analysis detected a major 4.5-kb ZNF266 transcript in HeLa cells, U-937 cells, and PMA-induced U-937 cells, with higher expression in the monocyte/macrophage lineages.
The International Radiation Hybrid Mapping Consortium mapped the ZNF266 gene to chromosome 19 (A008Z15).
Abrink, M., Aveskogh, M., Hellman, L. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. DNA Cell Biol. 14: 125-136, 1995. [PubMed: 7865130] [Full Text: https://doi.org/10.1089/dna.1995.14.125]