Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF273
Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38) : 7:64,877,603-64,937,316 (from NCBI)
Zinc finger proteins interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. ZNF273 belongs to the Kruppel-related family of zinc finger proteins (summary by Abrink et al., 1995).
See ZFP93 (604749) for additional information on zinc finger proteins.
By screening a U937 human monoblast cell line cDNA library with a degenerate oligonucleotide based on a conserved region of Kruppel-related zinc finger proteins encompassing the H/C link region, Abrink et al. (1995) isolated cDNAs encoding 42 distinct Kruppel-related zinc finger proteins, including ZNF273, which they called HZF9. The partial ZNF273 cDNA, which lacks 5-prime coding sequence, encodes 3 functional C-terminal zinc finger domains, followed by 1 degenerate finger motif, then 4 functional fingers, and finally 1 degenerate motif. Northern blot analysis detected a major 8.0-kb ZNF273 transcript in HeLa cells, U937 cells, and PMA-induced U937 cells, with higher expression in the monocyte/macrophage lineages and upregulation by PMA.
Gross (2021) mapped the ZNF273 gene to chromosome 7q11.21 based on an alignment of the ZNF273 sequence (GenBank BC063818) with the genomic sequence (GRCh38).
Abrink, M., Aveskogh, M., Hellman, L. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. DNA Cell Biol. 14: 125-136, 1995. [PubMed: 7865130] [Full Text: https://doi.org/10.1089/dna.1995.14.125]
Gross, M. B. Personal Communication. Baltimore, Md. 7/8/2021.