Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF254
Cytogenetic location: 19p12 Genomic coordinates (GRCh38) : 19:24,033,449-24,129,968 (from NCBI)
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (604749) for additional information on zinc finger proteins.
By sequencing cDNAs randomly selected from a cDNA library derived from human umbilical cord CD34+ cells, Mao et al. (1998) identified the ZNF254 gene, which they called HD-ZNF1. The full-length ZNF254 coding sequence encodes a 353-amino acid protein with sequence similarity to the Kruppel-related zinc finger protein HTF10, or ZNF91 (603971).
Han et al. (1999) also isolated a cDNA encoding ZNF254. The ZNF254 protein has 4 tandemly repeated C-terminal zinc finger motifs with interspersed conserved knuckle sequences, as well as an N-terminal Kruppel-associated box (KRAB). RT-PCR analysis detected variable expression of ZNF254 that was highest in monocytic cell lines.
By radiation hybrid mapping, Mao et al. (1998) mapped the ZNF254 gene to 19p13.12-p13.11.
Han, Z.-G., Zhang, Q.-H., Ye, M., Kan, L.-X., Gu, B.-W., He, K.-L., Shi, S.-L., Zhou, J., Fu, G., Mao, M., Chen, S.-J., Yu, L., Chen, Z. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. J. Biol. Chem. 274: 35741-35748, 1999. [PubMed: 10585455] [Full Text: https://doi.org/10.1074/jbc.274.50.35741]
Mao, M., Fu, G., Wu, J.-S., Zhang, Q.-H., Zhou, J., Kan, L.-X., Huang, Q.-H., He, K.-L., Gu, B.-W., Han, Z.-G., Shen, Y., Gu, J., Yu, Y.-P., Xu, S.-H., Wang, Y.-X., Chen, S.-J., Chen, Z. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc. Nat. Acad. Sci. 95: 8175-8180, 1998. [PubMed: 9653160] [Full Text: https://doi.org/10.1073/pnas.95.14.8175]